In American politics, a "single-issue interest group" means an organization that is (or claims to be) devoted exclusively to advocating one particular position on one particular policy issue. An "organization" might be a non-profit or a non-governmental organization (NGO), or a labor union, or a trade association, or a concerned citizens' group. Single-issue groups usually claim to be non-partisan (i.e., they support initiatives regardless of whether Democrats or Republicans advance them).
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