Answer:
In order for polar compounds to enter into the hydrophobic space of phospholipid tails, it would need to break the many hydrogen bonds
Explanation:
In the presence of water, the hydrophobic tails tend to interact with each other, creating a hydrophobic space from which water is excluded and in which other hydrophobic molecules can be trapped, while the polar head interacts with water, and is solvated, preserving the hydrophobic part from all contact with water. For a hydrogen bridge to form, a molecule that has hydrogen attached to an atom of high electronegativity and another molecule that has another electronegative atom with high electron density (that is, a negative partial charge) is required. Water molecules in the bulk of the body of water maintain multiple interactions with other molecules through an extensive network of hydrogen bridges, so for polar compounds to enter, it would be necessary to break many of these bonds.
