Voltage-gated sodium channels are the ion channels that conduct sodium ions. They are sensitive to the extracellular concentration of calcium ions.
Voltage-gated sodium channels are the signaling ion channels that are responsible for increasing the action potential of the nerve cells. VGSC is the most important resting and action potential of the cell.
These channels are sensitive to the high concentration of calcium ions as these ions cause the channels to open up on the membrane surfaces of the cell. This causes a change in the concentration of the gradient across the membrane.
Therefore, VGSC is sensitive to calcium ions.
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