Oxaloacetate is the starting compound and end result of the citric acid cycle.
The primary energy-yielding metabolic route in cells is the tricarboxylic acid cycle, which provides the majority of the reduced coenzymes that will be oxidized by the electron transport chain to produce adenosine triphosphate (ATP). The pathway is occasionally referred to as the Krebs' cycle or the citric acid cycle after its discoverer, Sir Hans Krebs. Citric acid cycle occurs in the intracellular space or matrix of the mitochondria of eukaryotes.
The cycle serves as the primary mechanism for the interconversion of 4- and 5-carbon molecules in the cell, many of which originate from or are intermediates in the synthesis of amino acids, in addition to its function in energy-yielding metabolism and the oxidation of 2-carbon units. In the fasted state, the primary precursor for gluconeogenesis is oxaloacetate, a significant cycle intermediary.
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