The stimuli causing endocrine glands to secrete their hormones in direct response to changing blood levels of certain critical ions and nutrients are called Humoral stimuli.
Humoral stimuli refer to the control of hormone release in response to changes in extracellular fluids such as blood or the ion concentration in the blood. For example, a rise in blood glucose levels triggers the pancreatic release of insulin.
The term humoral is derived from the term humor, which refers to bodily fluids such as blood. Insulin causes blood glucose levels to drop, which signals the pancreas to stop producing insulin in a negative feedback loop.
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