Most lipids are nonpolar. This property causes lipids to be water-insoluble in the bloodstream. Lipoproteins form water-soluble complexes for transport through the bloodstream by surrounding nonpolar lipids with polar phospholipids and proteins .
A central hydrophobic core of non-polar lipids, predominantly cholesterol esters and triglycerides, makes up the complex particles known as lipoproteins. Since lipids like cholesterol and triglycerides are not soluble in water, they must be carried in the bloodstream along with proteins called lipoproteins.
These lipoproteins are essential for the small intestine to absorb and transport dietary lipids, for lipids to travel from the liver to peripheral tissues, and for lipids to travel from peripheral tissues to the liver and intestine.
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