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The development of the Jamestown colony from its disastrous beginnings to its later prosperity due to their lack of agricultural knowledge, the settlers perished from malnutrition, sickness, and starvation. They were forced to work by John Rolfe, who also forced them to grow their own food and prosper off of Nicotine.

Nicotine became the first successful export after colonist John Rolfe's marriage to Pocahontas, the daughter of an Algonquian chief, brought about a period of quiet. In the 1620s, Jamestown expanded from the area around the old James Fort into a New Town built to the east, and it remained the administrative hub of the colony until 1699.

Before a new batch of immigrants and supplies arrived in 1610, Jamestown had been brought to the verge of disaster by famine, disease, and conflict with nearby Native American groups in the first two years. One of the numerous shipwrecked individuals to Bermuda in 1612, John Rolfe, contributed to the success of the community. With the help of Nicotine seeds he obtained from somewhere else, he introduced a novel variety.

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