In regions where malaria is present, it acts as a selective agent that favors the heterozygous phenotype, because people with sickle-cell trait produce more offspring than those with only normal hemoglobin, who may die of malaria.
(A) False.
(B) True.

The sickle cell anemia is mainly caused due to the point mutation in which the shape of the hemoglobin get disrupt. The GAG codon is replaced by GUG which codes for valine instead of glutamic acid.

The people with the heterozygous condition for this trait get an advantage in the malaria prone region because their hemoglobin shape does not allow the growth of plasmodium. The organism with sickle cell trait produce more offspring of Plasmodium and may die of malaria.

Thus, the correct answer is option (b).

​In regions where malaria is present, it acts as a selective agent that favors the heterozygous phenotype, because people with sickle-cell trait produce more offspring than those with only normal hemoglobin, who may die of malaria. (A) False. (B) True.

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In regions where malaria is present, it acts as a selective agent that favors the heterozygous phenotype, because people with sickle-cell trait produce more offspring than those with only normal hemoglobin, who may die of malaria.
(A) False.
(B) True.