A hypertensive patient was prescribed the diuretic Lasix (furosemide) to increase urinary output. Furosemide, a "high-ceiling" diuretic, is a potent agent because it binds to and inhibits which of the following transport processes?
A. The Na+-glucose cotransporter in the proximal tubule
B. The Na+-K+ exchange pump in all nephron segments
C. The Na+-K+-C-cotransporter in the thick ascending limb
D. The Na+-Cl- cotransporter in the distal convoluted tubule
E. The Na+ channel in the cortical collecting duct
Furosemide is a handle diuretic or also called high-efficiency, acting on the thick ascending branch of the Henle Handle, inhibiting the tubular reabsorption of Sodium, Chloride and Potassium (Na, Cl, K).
