The map shows the Fertile Crescent. A map of the Fertile Crescent. The Fertile Crescent begins at the northern end of the Persian Gulf, continues north and west following the Euphrates River and Tigris River, and narrows down the western coast of the Syrian Desert ending in Egypt. The Caspian Sea in north and east of the Fertile Crescent. The Mediterranean Sea is west of the Fertile Crescent. The Red Sea is south of the Fertile Crescent. The Persian Gulf is south and east of the Fertile Crescent. The Nile River is east of the Red Sea. The Jordan River is north of the Red Sea. The Zagros Mountains are north and east of the Persian Gulf. Asia Minor is located northwest of Mesopotamia. Which river helped establish direct trade between the people of the Fertile Crescent and Asia Minor? the Nile River the Tigris River the Jordan River the Euphrates River