Which of the following is used to generate diversity in the antibody repertoire? a. All of the answers are correct. b. Presence of multiple variable gene segments that can be assembled in multiple different combinations c. Ability to pair a single heavy chain with different light chains, so as to avoid generation of autoreactive antibodies d. Exonuclease trimming of excess nucleotides at variable segment junctions e. Addition of N nucleotides that are not encoded in the germ line

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02-11-2020
Biology

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Which of the following is used to generate diversity in the antibody repertoire? a. All of the answers are correct. b. Presence of multiple variable gene segments that can be assembled in multiple different combinations c. Ability to pair a single heavy chain with different light chains, so as to avoid generation of autoreactive antibodies d. Exonuclease trimming of excess nucleotides at variable segment junctions e. Addition of N nucleotides that are not encoded in the germ line

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Surnia Surnia · Answer 1 · 2020-11-06T03:12:30+01:00

Answer: a. All of the answers are correct.

Explanation:

Antibody are special proteins which are produced with respect to the antigens of the attacking pathogens.

Antibody repertoire can be defined as the set of the antibodies produced with respect to a particular tissue, or antigen.

Multiple ways are possible that contributes to the diversification of the antibody repertoire.

The mechanism of the antibody diversity includes the different variable, joined segments of gene particularly in the heavy chains and light chains and diversity.

There can be differential pairing between the light and heavy chains of antibodies. Other mechanisms comprises of somatic mutations including the gene segment (N region) and exonuclease trimming of the nucleotides.