Answer:
Chromosome 17 is made of over million (80) base pairs.
Approximately how many genes are found on chromosome 17?
1600
Explanation:
took on edge2020 and got it right
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Answer:
Adding to the answer already... feel free to cut and paste what you need
Explanation:
tumor suppressor of this type of gene leads to deregulated cellular proliferation, as in cancer. In a person born with two normal copies of a tumor suppressor gene, both copies must be inactivated by spontaneous point mutation, deletion, or failure of expression before tumor formation occurs. An inherited mutation in a tumor suppressor gene is the basis of most familial predispositions to cancer. In a person so predisposed, malignant cellular proliferation does not occur until the remaining intact copy of the gene is inactivated by deletion of part or all of its chromosome. Of many tumor suppressor genes thus far identified, the p53 gene on chromosome 17, which encodes a phosphoprotein that suppresses cell proliferation, appears to be the most important. Mutations of p53 have been found in the DNA of more than half of all human cancers studied. Li-Fraumeni syndrome, characterized by early-onset carcinomas and sarcomas, is an inherited (autosomal dominant) mutation in the p53 tumor suppressor gene. BRCA1 and BRCA2, involved in familial early-onset breast cancer as well as ovarian and other cancers in people of both sexes, are tumor suppressor genes.
Breast cancer is cancer that forms in the cells of the breasts.
Signs and symptoms of breast cancer may include:
A breast lump or thickening that feels different from the surrounding tissue
Change in the size, shape or appearance of a breast
Changes to the skin over the breast, such as dimpling
A newly inverted nipple
Peeling, scaling, crusting or flaking of the pigmented area of skin surrounding the nipple (areola) or breast skin
Redness or pitting of the skin over your breast, like the skin of an orange
Charcot-marine-tooth syndrome is a group of inherited disorders that cause nerve damage. This damage is mostly in the arms and legs (peripheral nerves). Charcot-Marie-Tooth disease is also called hereditary motor and sensory neuropathy.
Charcot-Marie-Tooth disease results in smaller, weaker muscles. You may also experience loss of sensation and muscle contractions, and difficulty walking. Foot deformities such as hammertoes and high arches also are common. Symptoms usually begin in the feet and legs, but they may eventually affect your hands and arms.
Symptoms of Charcot-Marie-Tooth disease typically appear in adolescence or early adulthood, but may also develop in midlife.
Signs and symptoms of Charcot-Marie-Tooth disease may include:
Weakness in your legs, ankles and feet
Loss of muscle bulk in your legs and feet
High foot arches
Curled toes (hammertoes)
Decreased ability to run
Difficulty lifting your foot at the ankle (footdrop)
Awkward or higher than normal step (gait)
Frequent tripping or falling
Decreased sensation or a loss of feeling in your legs and feet
As Charcot-Marie-Tooth disease progresses, symptoms may spread from the feet and legs to the hands and arms. The severity of symptoms can vary greatly from person to person, even among family members.
Charcot-Marie-Tooth disease is an inherited, genetic condition. It occurs when there are mutations in the genes that affect the nerves in your feet, legs, hands and arms.
Sometimes, these mutations damage the nerves. Other mutations damage the protective coating that surrounds the nerve (myelin sheath). Both cause weaker messages to travel between your limbs and brain.
Charcot-Marie-Tooth disease is hereditary, so you're at higher risk of developing the disorder if anyone in your immediate family has the disease.
Other causes of neuropathies, such as diabetes, may cause symptoms similar to Charcot-Marie-Tooth disease. These other conditions can also cause the symptoms of Charcot-Marie-Tooth disease to become worse. Medications such as the chemotherapy drugs vincristine (Marqibo), paclitaxel (Abraxane) and others can make symptoms worse. Be sure to let your doctor know about all of the medications you're taking.
Complications of Charcot-Marie-Tooth disease vary in severity from person to person. Foot abnormalities and difficulty walking are usually the most serious problems. Muscles may get weaker, and you may injure areas of the body that experience decreased sensation.
Sometimes the muscles in your feet may not receive your brain's signal to contract, so you're more likely to trip and fall. And your brain may not receive pain messages from your feet, so if you've rubbed a blister on your toe, for example, it may get infected without your realizing it.
You may also experience difficulty breathing, swallowing or speaking if the muscles that control these functions are affected by Charcot-Marie-Tooth disease.
