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- The Spanish, threatened by the Portuguese monopoly on enslaved Africans and expansion in the Atlantic, started their own colonization project with Christopher Columbus in 1492.
- The Columbian exchange, also known as the Columbian interchange, named after Christopher Columbus, was the widespread transfer of plants, animals, culture, human populations, technology, diseases, and ideas between the Americas, West Africa, and the Old World in the 15th and 16th centuries.
- Luther came to reject several teachings and practices of the Roman Catholic Church. He strongly disputed the claim that freedom from God's punishment for sin could be purchased with money, proposing an academic discussion of the practice and efficacy of indulgences in his Ninety-five Theses of 1517.
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