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It seems that you have missed the necessary options for us to answer this question, but anyway, hope this information may help you. Duomo in Florence is one of its Cathedrals which stands tall over the city with its magnificent Renaissance dome designed by Filippo Brunelleschi. The cathedral is named such in honor of Santa Maria del Fiore. Hope this answer helps.
The answer is D. built by Brunelleschi, it was inspired by the Pantheon in Rome. 
The rest of the answers for this quick check are 
1) it made people reconsider views of government and political power 2) they were interested in inquiry and exploration as well as the idea the humans could perfect themselves 3) scholars focused more on secular humanities 4) Humanity progresses by building upon past knowledge 5) realism, as in his painting of the Mono Lisa 6) built by Brunelleschi, it was inspired by the pantheon in Rome 7)by valuing classical learning 8) it used an ancient Greek or Roman art form 9) to support the idea that commerce centered in Italy led to the Renaissance 10) genoa Naples and Venice