Which sentence from the section "Evidence of change" BEST supports the idea that man-made creations are altering the planet?

Question 1 options:

Nuclear energy is another powerful force that humans have developed.


It was mostly due to humans burning fossil fuels in the last 250 years.


Another way that humans are changing Earth's systems lies in our ability to create artificial chemicals like drugs, pesticides, plastics, and synthetic fabrics.


Since the beginning of human agriculture, the atmospheric concentration of CO2 has risen from 280 ppm to about 390 ppm.