Respuesta :
The suppression of glycolysis is responsible for a large portion of the control of gluconeogenesis.
Discussion about the statement:
The cytosol is the site of all glycolysis and gluconeogenesis processes. The rate at which glucose is produced in the body is inversely related to the intake of carbohydrates. The suppression of glycolysis is responsible for a large portion of the control of gluconeogenesis.
Fructose 2,6-bisphosphate is an intermediate that plays a crucial role in controlling both glycolysis and gluconeogenesis. This metabolite's presence can promote glycolysis and prevent gluconeogenesis.
Control of Gluconeogenesis and Glycolysis
- At various crucial stages of glycolysis and gluconeogenesis, metabolic control takes place. The catalysts that accelerate each of these stages can be activated or inhibited by outside forces, for example, the quantity of a molecule that comes after. The conversion of glucose and ATP into glucose 6-phosphate is the first controlled step in glycolysis. Keep in mind that hexokinase catalyzes this process.
- High levels of blood glucose, AMP, and low levels of cellular ATP all trigger the activation of hexokinase. In other words, the glycolysis process is enhanced when blood glucose levels are high. Whenever cellular ATP levels are low and AMP levels are high, glycolysis is also increased. Both of these instances show that the cell is short on energy and may be directly influenced to create additional energy.
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