The most accurate example of a primary endocrine pathology in the pathway controlling cortisol secretion is Dysfunction in the adrenal cortex.
When the adrenal glands don't generate enough cortisol and occasionally aldosterone, it is called adrenal insufficiency. When the glands' outer layer, the adrenal cortex, is destroyed, the production falls. When you have an autoimmune condition that causes your body to attack the glands, this most frequently happens. Tumors, TB, and other diseases are also potential causes. Primary adrenal insufficiency is the name given to this condition.
A lack of adrenocorticotropin (ACTH), a hormone generated by the pituitary gland, results in secondary adrenal insufficiency, which is more frequent than the primary variety. Your adrenal glands won't produce enough cortisol if your pituitary doesn't produce enough ACTH.
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