When an allergen binds with IgE antibodies on mast cells, resulting in release of chemical mediators, this reaction is called Type I reactions.
The Type I reactions is also known as immediate hypersensitivity reaction.
This reaction involve immunoglobulin E ( IgE ) - mediated release of histamine and other mediators from mast cells and basophils .
Examples : anaphylaxis and allergic rhinoconjunctivitis.
The IgE molecules bind to high - affinity receptors on the surface of mast cells and basophils and the subsequently cross-linking of these molecules with the allergen releases performed and newly synthesized mediators.
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