Hybridoma cells resulting from the fusion of B lymphocytes and myeloma cells produce specific monoclonal antibodies. Hybridomas are generated by fusing spleen cells (plasma cells) from immunized hosts with a compatible myeloma cell line (malignant and immortal plasma cell line).
What is hybridomas?
- A hybriddoma is a culture of hybrid cells formed by the fusion of B and myeloma cells. Hybridoma technology gives rise to hybridomas.
- This technique was created to create mAbs. Hybridomas have two crucial B cell properties: antibody production and myeloma cell immortalization.
- Hybridoma technology ushered in a paradigm change by enabling the mass manufacture of extremely specific and sensitive monoclonal antibodies.
- The mAbs have been widely employed in diagnostics, including the detection of cancer. These are also widely utilized in cancer treatment.
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