A pharmaceutical company went bankrupt after investing in what they thought was a highly promising leptin-like drug for obesity. Their fatal mistake was not hiring and consulting you during drug development. What could you have told them to avert their demise?

Answer choices:
Their drug wasn't strong enough because it was oral and not intravenous


Leptin can't be given as a drug because it's a hormone


Suppression of appetite is not sufficient for reversing obesity


Leptin insensitivity is commonly associated with obesity


Orexin exists to counteract any leptin you introduce