The reason tetrodotoxin causes death so quickly is directly related to the loss of respiratory muscle function.
The sex organs (gonads) and liver of several fish, including puffer fish, globefish, and toadfish (order Tetraodontiformes), as well as in some amphibian, octopus, and clam species, contain the very toxic poison known as tetrodotoxin.
When the fish's flesh and/or organs are handled carelessly and consumed, human poisonings happen. Tetrodotoxin produces gradually progressive paralysis of the body's muscles by interfering with the transfer of impulses from nerves to muscles. Poisoning with tetrodotoxin may cause death.
By obstructing sodium channels, tetrodotoxin interferes with the flow of impulses from neurons to muscles. This causes the muscles, especially those in the respiratory system, to quickly weaken and paralyse, which can cause respiratory arrest and death.
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