The correct answer is Granulocyte colony-stimulating factor dysfunction is the factor for decreased number of mature.
Granulocyte-colony stimulating factor (G-CSF) is a hematopoietic growth factor that regulates neural stem cell proliferation and differentiation. Despite recent research into G-CSF-related mechanisms of action in various disease models, little is known about its function in the healthy brain. G-CSF is a growth factor that causes the bone marrow to produce more white blood cells, lowering the risk of infection after certain types of cancer treatment. G-CSF also causes some stem cells in the bone marrow to migrate into the blood. Granulocyte macrophage colony-stimulating factor is a growth factor that promotes the differentiation of granulocytes and macrophages, both of which are important in controlling the host's defense against pathogenic microbes.
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