It is to be noted that the specificity of an antibody is due to " the variable portions of the H and L chains." (Option E)
Antibody specificity can be interpreted as either a measure of the quality of fit between the antibody-combining site (paratope) and the associated antigenic determinant (epitope), or as the antibody's capacity to distinguish between similar or even different antigens.
Each antibody is made up of four polypeptides: two heavy chains and two light chains that are linked together to create a "Y" shaped structure. The amino acid sequence of the "Y" tips differs widely amongst antibodies. The antibody's specificity for binding antigen is determined by this variable region, which consists of 110-130 amino acids.
During B cell growth, V, D, and J gene recombination produce unbiased antibody specificity. This technique produces potentially harmful autoreactive cells as a byproduct.
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