By recognizing MAMPS inside the cell as opposed to outside it, NLRS differ from TLRS. RLRs recognize pathogen genome, while NLRs mostly detect intracellular bacteria.
Two important types of innate immune sensors, Toll-like receptors (TLRs) and Nod-like receptors (NLRs), offer prompt responses to pathogenic invasion or tissue damage. By interacting with damage/danger-associated molecular patterns (DAMPs), pathogen/microbe-associated molecular patterns (MAMPs), pathogen-associated molecular patterns (PAMPs), and xenobiotic-associated molecular patterns (MAMPS ), the TLRs become activated.
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