The most severe and immediate result of a burn is hypovolemia. It is mostly due to an increase in capillary permeability, which causes a shift of protein and fluid from the intravascular to the interstitial area. Hypovolemia causes "burn shock."
The pathophysiology of a burn wound is characterized by an inflammatory response that leads to fast oedema production as a result of enhanced microvascular permeability, vasodilation, and extravascular osmotic activity.
The objective of fluid management in large burn injuries is to preserve tissue perfusion during the early stages of burn shock, before hypovolemia develops owing to constant fluid extravasation from the intravascular compartment.
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