ACTH stimulates the adrenal cortex to produce cortisol. As plasma cortisol levels increase, ACTH secretion is suppressed. As cortisol levels decrease, ACTH increases.
What causes cortisol suppression?
Your adrenal glands can also become damaged from an infection or blood loss to the tissues (adrenal hemorrhage). All of these situations limit cortisol production.
What happens with hypersecretion of ACTH?
Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome.
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