The structure of the acetyl-CoA is -[SEE aatachemt]
The structure of the malonyl-CoA is -[SEE aatachemt]
The structure of the palmitic acid is -[SEE aatachemt]
So from comparing all the three structures, it is evident that the terminal carbon with attached O= will be the suitable carbon to radiolabel the malonyl-CoA as this carbon will remain in the resultant palmitate molecule to trace down.
A crucial intermediary metabolite in the synthesis of fatty acids is malonyl-CoA. Malonyl-coenzyme A (CoA) is the substrate that serves as the main carbon source for the synthesis of palmitate (C16), which is catalyzed by fatty acid synthase, in de novo fatty acid synthesis.
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