Read the quote from President Wilson’s letter to the National Child Labor Committee. “As the labor situation created by the war develops I am more interested than ever, if that were possible, in throwing all the safeguards possible around the labor of women and children.” The “labor situation” Wilson refers to most likely concerned him because:

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According to E2020 the answer is letter "B"  women and children had to do the jobs of male workers who became soldiers.

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Because Wilson was President during WWI. During this period, many men had to join the military to fight in Europe, leaving their work positions in the U. S. vacant. This gap in the workforce was often filled by women and children. This change in the nature of the workforce needed to be regulated, and this was a matter that concerned President Wilson.