Native Americans for the most part were not friendly. Who could blame them, since colonists were pretty much invading their territory, and they were kinda cruel. Probably due to fear or caution of native Americans.
Nevertheless, the native Americans were raiding colonists and their homes. This is probably the answer you are looking for. In turn, colonists took matter to their own hands and also hurt the native Americans.
Both sides' distrust of each other escalated to the point where native Americans eventually were nearly wiped out during the expansion of European colonists.
