The carbonic acid-bicarbonate buffer system functions mainly to __________.
neutralize the urine
take over the removal of CO2 from the plasma when the lungs aren't working properly
limit ECF pH changes caused by metabolism
prevent destructive changes in ICF pH due to cellular metabolism
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The carbonic acid-bicarbonate buffer system functions mainly to **limit changes in pH caused by metabolism**. This buffer system involves the balance of carbonic acid (H 2 CO 3), bicarbonate ion (HCO − 3), and carbon dioxide (CO 2) in order to maintain pH in the blood and other tissues, to support proper metabolic function². When any acidic substance enters the bloodstream, the bicarbonate ions neutralize the hydronium ions forming carbonic acid and water³. This system is critical for maintaining a constant blood pH, which is essential for the proper functioning of our body³. So, the correct answer would be "limit ECF pH changes caused by metabolism".