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The best phrase that best describes New York City's Little Italy is 'The city is an example of segregation by culture. '

"Little Italy is an example of segregation by culture" is the phrase that best describes New York's  Little Itay.

Little Italy is a the name to refer to an ethnic enclave populated by Italians or people of Italian ancestry, usually in an urban neighborhood. In this case, Little Italy in New York is placed in lower Manhattan. It comprises Italian restaurants, shops and other shops with the charasteristics of Italian culture.