Epinephrine and glucagon cause an increase in the blood glucose level. Epinephrine acts when a higher than normal level of glucose is required; glucagon acts when the level is unusually low. Both stimulate gluconeogenesis and glycogen breakdown and decrease glycolysis and glycogen synthesis. Insulin causes a decrease in blood glucose levels; it acts by increasing glycogen synthesis, glycolysis, and glucose uptake by cells as well as by decreasing glycogen breakdown.
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